Together with chemists of Division of Physico-Inorganic Chemistry of Institute of General and Inorganic Chemistry of NASU (Kyiv, Ukraine) possibility of biomedical applications of macrocyclic metallocomplexes, particularly as inhibitors of amyloidogenesis is studied.
In collaboration with Prof. Vinod Subramanian (University of Twente, The Netherlands) we carry out the study of beta-pleated protein formations with the help of amyloid-sensitive fluorescent dyes.
We collaborate with the group of P rof. Alexander Kotlyar (Department of Biochemistry, Tel Aviv University, Israel) in the field of the study of dyes binding with the four-stranded DNA motifs.
In collaboration with the groups of Prof. O.I. Tolmachev (Institute of Organic Chemistry, Kyiv, Ukraine) studies of cyanine dyes as fluorescent probes for nucleic acids and proteins are carried out.
In cooperation with Prof. Alexandre Boutorine (Museum National d'Histoire Naturelle, Paris, France) we work on development of the groove-binding probes specific to the double-stranded DNA sequences and on the study of dye-DNA interaction.
Since 2006 we collaborate with the group of Prof. Paulo F. Santos (Department of Chemistry, The University of Tras -os-Montes and Alto Douro, Vila Real, Portugal) in the field of the study of spectral-luminescent properties of squaraine dyes as fluorescent probes for the detection of biological molecules.
In cooperation with Dr. Olexander V. Manaev (D. Mendeleev University of Chemical Technology of Russia, Moscow, Russia) spectral-luminescent characteristics of styryl dyes and their interaction with biological molecules are studied.
In collaboration with Prof Yuriy V. Malyukin from the Institute for Scintillation materials (STC «Institute for Single Crystals», NAS of Ukraine, Kharkiv, Ukraine) we study the aggregation processes of dyes in aqueous solutions as well as in the presence of nucleic acids.
We collaborate with
Dr. Piero Bianco (Department of Microbiology and Immunology of State
University New York at Buffalo, USA) in the field of development of
fluorescent dyes for the dsDNA visualization in single molecule detection
experiments.
Research Group of Photonics of Organic Media under the guidance of Prof Valeriy M. Yashchuk (Physics Faculty, Kyiv Taras Shevchenko National University) collaborates with our group in study of the energy transfer processes in DNA-cyanine dye system.
