| |
 |
|
Doctor of Science Sergiy Yarmoluk, Head of Department
|
 |
 |
1979
– Specialist degree in chemistry, Chemical Faculty of Kyiv
Taras Shevchenko National University. From 1979 Sergiy worked
in Protein Chemistry Division, Institute of Molecular Biology
and Genetics of National Academy of Sciences of Ukraine (IMBG),
where he carried out the protease inhibitor synthesis under
the supervision of Prof. S.B. Serebryany. In 1983 he joined
the Oligonucleotides Synthesis Group, and in 1985 Sergiy started
his work in the Synthesis and Study of Biospecific Compounds
Lab of the IMBG. 1993 – Ph.D. degree in Bioorganic Chemistry.
The Ph.D thesis was devoted to the synthesis and study of
oligonucleotides modified with peptide residues and was performed
at Novosibirsk Institute of Biooganic Chemistry (Russia) under
Prof. V. Zarytova supervision. 1993 – Sergiy joined Nucleic
Acids Chemistry Division at IMBG where he performed the synthesis
of nucleoside-amino acids conjugates.
In 1996 Sergiy became the Head of the Nucleic Acids Chemistry
Research Group of IMBG. 2005 – Doctor's degree in Bioorganic
Chemistry. The doctoral thesis was devoted to design of the
fluorescent probes based on cyanine dyes for nucleic acids
and proteins detection and was performed at Institute of Bioorganic
Chemistry and Petrochemistry of National Academy of Sciences
of Ukraine. In 2006 Sergiy was given the rank of Professor
in bioorganic chemistry.
Now Sergiy is the Head of Department of Combinatorial Chemistry
of the IMBG. He is a member of Permanent Steering Committee
(PSC) of the Conference on Methods and Applications of Fluorescence
(MAF); Biological Stain Commission, University of Rochester,
Medical Center, USA. Sergiy is a Deputy Editor of the first
Ukrainian bioorganic on-line journal Ukrainica
Bioorganica Acta and a member of the editorial board of
Biotechnic & Histochemistry journal (Great Britain).
Dr. Sergiy M. Yarmoluk is a co-author of 250 papers published
in scientific journals.
The research interests of Sergiy are development of fluorescent
probes for homogeneous detection of biopolymers, studies of
biding mechanism of cyanine dyes with nucleic acids and proteins.
Sergiy first proposed β-modified cyanine dyes for the nucleic
acids detection, as well as principle of “affinity-modifying
group” for the development of biopolymers-specific fluorescent
probes. Also he proposed model of “half intercalation” of
the cyanine dyes into DNA.
Sergiy was the principle investigator of the number of joint
projects and contracts: with National Lab of Livermor (USA,
2001); Active Motif Chromeon Gmb (Germany, 2001, patent US2003175988);
Research and Development Department of Fluka Chemie GmbH (Switzerland,
three contracts during 2001-2005 years, patent US2006207881);
Bio-Rad Laboratories (2005, patent Application WO 2008/027821
A1); State University of New York at Buffalo (USA, 2004) in
the frames of STCU.
|
|
E-mail:
sergiy@yarmoluk.org.ua
|
 |
|
©
YARMOLUK RESEARCH LAB
|
 |
